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When patients hear the word ketamine, many think of nightclubs, “Special K,” or headlines about overdose. So it’s a fair question: Isn’t ketamine a party drug?

Ketamine therapy is an emerging treatment option for certain mental health conditions — most commonly treatment‑resistant depression — and, in some settings, severe suicidal ideation. Originally developed as an anesthetic in the 1960s, ketamine is now being used at much lower, sub‑anesthetic doses to target mood symptoms. If you’re hearing about ketamine for the first time, here’s what you need to know. 1. What Is Ketamine? Ketamine is a medication that works differently